Publications

@article{Belic2019264,

title = {Thermochromic behaviour and thermodynamics of cobalt(II) chloride complexes in ammonium nitrate + N-methylformamide mixture},

author = {S. Belić and M. Vraneš and S. Papović and J. Magyari and M. Rodić and S. Gadžurić},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062666115&doi=10.1016%2fj.molliq.2019.02.130&partnerID=40&md5=7dc8bdf629f5bd81796311d474aa72db},

doi = {10.1016/j.molliq.2019.02.130},

issn = {01677322},

year  = {2019},

date = {2019-01-01},

journal = {Journal of Molecular Liquids},

volume = {282},

pages = {264-274},

publisher = {Elsevier B.V.},

abstract = {In this paper thermochromic features of cobalt(II) were investigated in the binary mixture containing inorganic salt (ammonium nitrate) and molecular solvent (N-methylformamide) in order to find responsive thermochromic medium for possible application in a greenhouses for auto-regulated shading and solar protection. Absorption spectra of cobalt(II) in the NH 4 NO 3 + zNMF (z = 3, 4, 5, 6 and 20) binary mixtures were recorded in the visible wavelength range in the presence of different cobalt(II) and chloride concentrations at five selected temperatures: 308.15; 318.15; 328.15; 338.15 and 348.15 K. From the obtained spectra, geometry, composition and speciation of the complexes were discussed. Influences of the temperature and mixture composition on the absorption spectra were also analysed. From an analysis of the spectra using two computer programs, it was concluded that the following complexes were formed: [Co(NO 3 ) 4 (NMF) 2 ] 2− , [CoCl 3 (NO 3 )(NMF) 2 ] 2− and [CoCl 4 ] 2− . For these complexes stability constants were determined at all temperatures. Thermodynamic parameters were also calculated using the temperature dependence of calculated stability constants. © 2019 Elsevier B.V.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Kovacevic2019684,

title = {Asymmetric synthesis of the cytotoxic lactone (+)-cardiobutanolide and two novel analogues},

author = {I. Kovačević and M. Popsavin and M. V. Rodić and V. Kojić and V. Popsavin},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060991224&doi=10.1016%2fj.tetlet.2019.01.059&partnerID=40&md5=9196430ef9833fb6599cfa31c7311a38},

doi = {10.1016/j.tetlet.2019.01.059},

issn = {00404039},

year  = {2019},

date = {2019-01-01},

journal = {Tetrahedron Letters},

volume = {60},

number = {9},

pages = {684-687},

publisher = {Elsevier Ltd},

abstract = {A new asymmetric synthesis of the naturally occurring styryl lactone cardiobutanolide and two novel analogues have been achieved starting from D-xylose. The key steps of the synthesis included an initial zinc mediated reductive THF-ring opening, stereoselective olefination and Sharpless asymmetric dihydroxylation. It was shown that cardiobutanolide (1) exhibits promising in vitro antitumour properties against certain human neoplastic cell lines. It was more potent than the commercial anticancer agent doxorubicin against three cell lines (K562, HL-60 and Raji). © 2019 Elsevier Ltd},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Rodic2019467,

title = {Synthesis and crystal structure of copper(II) complexes with pyridoxal S-methylisothiosemicarbazone bearing a new coordination mode},

author = {M. V. Rodić and M. M. Radanović and L. S. Vojinović-Ješić and S. K. Belošević and Ž. K. Jaćimović and V. M. Leovac},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85067263432&doi=10.2298%2fJSC190114008R&partnerID=40&md5=d0bc3c93009a3af86cb8b42cc2abb9d7},

doi = {10.2298/JSC190114008R},

issn = {03525139},

year  = {2019},

date = {2019-01-01},

journal = {Journal of the Serbian Chemical Society},

volume = {84},

number = {5},

pages = {467-476},

publisher = {Serbian Chemical Society},

abstract = {The reaction of copper(II) nitrate and pyridoxal S-methylisothiosemi-carbazone (PLITSC) in the presence of ammonium thiocyanate resulted in the formation of two types of complexes. A dimeric complex of the formula [Cu(μ-PLITSC)NCS2](NCS)2·2MeOH was obtained in the presence of excess of ammonium thiocyanate, while in the presence of its nearly equimolar amount, crystals of a polymeric complex [Cu(μ-PLITSC)NCS]NO3∙MeOHn were formed. The complexes were characterized by elemental analysis, con-ductometry, IR spectroscopy, and their structures are unequivocally determined by single crystal X-ray crystallography. In both complexes, the copper atom is five-coordinated, situated in a deformed square-pyramidal environment. The basal plane of the square pyramid is defined by the oxygen atom of the deprotonated phenol group and terminal nitrogen atoms of the isothiosemicarbazide moiety of the Schiff base, as well as the nitrogen atom of the coordinated thiocyanate ion, while the apical site is occupied by the oxygen atom of the hydroxymethyl group of the neighboring asymmetric unit. This coordination mode of the PLITSC was hitherto unknown. A survey of the Cambridge Structural Database showed that the coordination of the hydroxymethyl group is rare within pyridoxal-based Schiff base metal complexes. © 2019 Serbian Chemical Society. All rights reserved.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Rodic2019111,

title = {Comments on DFT calculation, biological activity, anion sensing studies and crystal structure of (E)-4-chloro-2-((pyridin-2-ylimino)-methyl)phenol by Nuray Yıldırım, Neslihan Demir, Gökhan Alpaslan, Bahadir Boyacıoğlu, Mustafa Yıldız and Huseyin Ünver, published in the Journal of the Serbian Chemical Society, Volume 83, Issue 6, 2018, pp. 707–721},

author = {M. V. Rodić},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065437708&doi=10.2298%2fJSC180925082R&partnerID=40&md5=12e8e15e43bed3401f2122d9ff12c920},

doi = {10.2298/JSC180925082R},

issn = {03525139},

year  = {2019},

date = {2019-01-01},

journal = {Journal of the Serbian Chemical Society},

volume = {84},

number = {1},

pages = {111-116},

publisher = {Serbian Chemical Society},

abstract = {The crystal structure of (E)-4-chloro-2-((pyridin-2-ylimino)-methyl)-phenol, recently published by Yıldırım et al. in J. Serb. Chem. Soc. 83 (2018) 707–721, is revised. Refinement of the new structural model against original X-ray diffraction data, deposited with the Cambridge Crystallographic Data Centre, proved that the compound studied by single crystal X-ray diffraction was actually (E)-4-chloro-2-((pyridin-3-ylimino)methyl)phenol. © 2019 Serbian Chemical Society. All rights reserved.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Bjelogrlic201945,

title = {A novel binuclear hydrazone-based Cd(II) complex is a strong pro-apoptotic inducer with significant activity against 2D and 3D pancreatic cancer stem cells},

author = {S. Bjelogrlić and T. R. Todorović and I. Cvijetić and M. V. Rodić and M. Vujčić and S. Marković and J. B. Araškov and B. Janović and F. Emhemmed and C. D. Muller and N. R. Filipović},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85055090720&doi=10.1016%2fj.jinorgbio.2018.10.002&partnerID=40&md5=dd6d19729559fb60333c6f81e7ab9ca3},

doi = {10.1016/j.jinorgbio.2018.10.002},

issn = {01620134},

year  = {2019},

date = {2019-01-01},

urldate = {2019-01-01},

journal = {Journal of Inorganic Biochemistry},

volume = {190},

pages = {45-66},

publisher = {Elsevier Inc.},

abstract = {A novel binuclear Cd complex (1) with hydrazone-based ligand was prepared and characterized by spectroscopy and single crystal X-ray diffraction techniques. Complex 1 reveals a strong pro-apoptotic activity in both human, mammary adenocarcinoma cells (MCF-7) and pancreatic AsPC-1 cancer stem cells (CSCs). While apoptosis undergoes mostly caspase-independent, 1 stimulates the activation of intrinsic pathway with noteworthy down regulation of caspase-8 activity in respect to non-treated controls. Distribution of cells over mitotic division indicates that 1 caused DNA damage in both cell lines, which is confirmed in DNA interaction studies. Compared to 1, cisplatin (CDDP) does not achieve cell death in 2D cultured AsPC-1 cells, while induces different pattern of cell cycle changes and caspase activation in 2D cultured MCF-7 cells, implying that these two compounds do not share similar mechanism of action. Additionally, 1 acts as a powerful inducer of mitochondrial superoxide production with dissipated trans-membrane potential in the majority of the treated cells already after 6 h of incubation. On 3D tumors, 1 displays a superior activity against CSC model, and at 100 μM induces disintegration of spheroids within 2 days of incubation. Fluorescence spectroscopy, along with molecular docking show that compound 1 binds to the minor groove of DNA. Compound 1 binds to the human serum albumin (HSA) showing that the HSA can effectively transport and store 1 in the human body. Thus, our current study strongly supports further investigations on antitumor activity of 1 as a drug candidate for the treatment of highly resistant pancreatic cancer. © 2018 Elsevier Inc.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Svircev_2018_4761,

title = {Conformationally restricted goniofufurone mimics with halogen, azido or benzoyloxy groups at the C-7 position: Design, synthesis and antiproliferative activity},

author = {M. Svirčev and G. Benedeković and I. Kovačević and M. Popsavin and V. Kojić and D. Jakimov and T. Srdić-Rajić and M. V. Rodić and V. Popsavin},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050890669&doi=10.1016%2fj.tet.2018.07.046&partnerID=40&md5=249401854a217f7be69b05c836081525},

doi = {10.1016/j.tet.2018.07.046},

issn = {00404020},

year  = {2018},

date = {2018-01-01},

journal = {Tetrahedron},

volume = {74},

number = {36},

pages = {4761-4768},

publisher = {Elsevier Ltd},

abstract = {A series of new conformationally restricted goniofufurone mimics, bearing an additional 1,3-dioxan ring and a halogen, azido or benzoyloxy functionality at the C-7 position has been designed and synthesized. The Appel reaction was used for replacement of 7-OH group with Cl or Br functions in tricyclic lactone (3). 7-Iodo derivative (3d) was prepared by using the Ph3P/I2/2,6-lutidine reagent system. 7-Fluoro group was introduced by treatment of 3 with DAST, while the corresponding 7-azido and 7-benzoyloxy derivatives have been prepared by multistep sequences. Synthesized products were evaluated for their ability to inhibit growth of selected human malignant cell lines. Structure-activity relationships demonstrated that the nature of a substituent at the C-7 position could enhance the antiproliferative activity of the analogues. The preliminary study on the mechanisms indicated that all synthesized compounds induced apoptosis in 61–77% of K562 cells. © 2018 Elsevier Ltd},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Jacimovic_2018_813,

title = {Synthesis and characterization of copper, nickel, cobalt, zinc complexes with 4-nitro-3-pyrazolecarboxylic acid ligand},

author = {Ž. Jaćimović and M. Kosović and V. Kastratović and B. B. Holló and K. M. Szécsényi and I. M. Szilágyi and N. Latinović and L. Vojinović-Ješić and M. Rodić},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048654925&doi=10.1007%2fs10973-018-7229-4&partnerID=40&md5=54c3be4bab84aa21af176e5f67cc1b96},

doi = {10.1007/s10973-018-7229-4},

issn = {13886150},

year  = {2018},

date = {2018-01-01},

journal = {Journal of Thermal Analysis and Calorimetry},

volume = {133},

number = {1},

pages = {813-821},

publisher = {Springer Netherlands},

abstract = {In the continuation of our systematic research of pyrazole coordination compounds, complexes of Cu(II), Ni(II), Co(II) and Zn(II) with 4-nitro-3-pyrazolecarboxylic acid ligand (L) were synthesized in the reaction of warm ethanolic solutions of the ligand and CuCl2·2H2O, Ni(CH3COO)2, CoCl2·6H2O and Zn(CH3COO)2, mixed in the metal-to-ligand ratio of 1:2. As the compounds could not be obtained in the form suitable for single-crystal structure analysis, their bis(ligand) structures, ML2 (M = CuII, NiII, CoII and ZnII) were proposed on the basis of elemental analysis, IR spectrometry, conductometric and TG–MS measurements. The low conductivity of the compounds additionally supports the deprotonation of the ligand and the formation of neutral complexes. The solvent content was calculated using the thermogravimetric (TG) data. According to TG data, the copper(II) compound crystallizes with 8 while nickel(II) complex with 4 water molecules, CuL2·8H2O, NiL2·4H2O. Complexes of Co(II) and Zn(II) contain 1 and 1.5 water molecules. Despite the differences in solvation properties, the high similarity in the course of the decomposition refers to the similar coordination mode of the organic ligand. The crystal and molecular structures of HL·H2O and NH4[LHL] were determined by single-crystal X-ray structure analysis. Biological research based on determining the inhibition effect of commercial fungicide Cabrio top, ligand, and all newly synthesized complexes on Ph. viticola has been carried out using the phytosanitary method. © 2018, Akadémiai Kiadó, Budapest, Hungary.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Magyari_2018_443,

title = {Synthesis and characterization of diazine-ring containing hydrazones and their Zn(II) complexes},

author = {J. Magyari and B. Barta Holló and M. V. Rodić and I. M. Szilágyi and K. Mészáros Szécsényi},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038099435&doi=10.1007%2fs10973-017-6908-x&partnerID=40&md5=68fe21030247a7c724483fa6ac84b9f1},

doi = {10.1007/s10973-017-6908-x},

issn = {13886150},

year  = {2018},

date = {2018-01-01},

journal = {Journal of Thermal Analysis and Calorimetry},

volume = {133},

number = {1},

pages = {443-452},

publisher = {Springer Netherlands},

abstract = {Two new zinc(II) coordination compounds have been synthesized by the reaction of diazine-ring containing Schiff bases di(2-pyridyl) ketone phthalazine-1-hydrazone (HzDPK) and di(2-pyridyl) ketone 3-chloropyridazine-6-hydrazone (HpDPK) with zinc(II) salts in acetonitrile in the presence of triethylamine. The crystal and molecular structures of the complexes and that of the ligand HpDPK were determined by single-crystal X-ray structure analysis. In both complexes, zinc atoms are situated in distorted octahedral environments, formed by two meridionally coordinated NNN tridentate, mono-deprotonated ligands. Since the applicability of the coordination compounds depends on their thermal properties, the thermal decomposition of the ligands and their complexes was followed by simultaneous TG–DSC measurements. The desolvation process of the complexes is rather slow as a consequence of a restricted diffusion through the lattice and finishes ~ 200 °C. The desolvated compounds are stable up to 340 °C. In order to follow the solvent evaporation and to have a better insight into the decomposition mechanism of the compounds coupled TG–MS measurements were carried out. © 2017, Akadémiai Kiadó, Budapest, Hungary.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Radanovic_2018_160,

title = {Complexes of Zn(II) and Cd(II) with 2-acetylpyridine -aminoguanidine – Syntheses, structures and DFT calculations},

author = {M. M. Radanović and M. V. Rodić and L. S. Vojinović-Ješić and S. Armaković and S. J. Armaković and V. M. Leovac},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043773511&doi=10.1016%2fj.ica.2017.12.038&partnerID=40&md5=541af6e4dfcbff2ee9c6b9d125166552},

doi = {10.1016/j.ica.2017.12.038},

issn = {00201693},

year  = {2018},

date = {2018-01-01},

journal = {Inorganica Chimica Acta},

volume = {473},

pages = {160-168},

publisher = {Elsevier S.A.},

abstract = {The reaction of 2-acetylpyridine-aminoguanidine dihydrogenchloride (L·2HCl) with Zn(II) and Cd(II) ions, in the presence of deprotonating agent (LiOAc) and without it, yielded two types of complexes, i.e. neutral [Zn(L)Cl2]·H2O and [Cd(L)Cl2] and anionic complexes [H2L][ZnCl4]·H2O and [H2L]2[Cd2Cl8(H2O)2], respectively. In the latter two compounds, 2-acetylpyridine-aminoguanidine does not coordinate the metal and has the role of counter ion. Complexes are characterized by elemental analysis, IR spectroscopy, conductometric measurements and single crystal X-ray analysis. In the neutral complexes, chelating ligand is coordinated in an expected tridentate N3 coordination mode via pyridine, azomethine, and nitrogen atom of the imino group of the aminoguanidine residue. Density functional theory (DFT) calculations have been used in order to investigate local reactivity properties of the newly synthesized complexes. Charge transfer within molecule as a consequence of light absorption has been investigated employing the time dependent DFT calculations and formalism of natural transition orbitals. DFT calculations have been also used in order to evaluate fundamental optoelectronic properties. © 2018 Elsevier B.V.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Francuz_2018_2017,

title = {Novel: O -methyl goniofufurone and 7- epi -goniofufurone derivatives: Synthesis, in vitro cytotoxicity and SAR analysis},

author = {J. Francuz and M. Popsavin and S. Djokić and V. Kojić and T. Srdić-Rajić and M. V. Rodić and D. Jakimov and V. Popsavin},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85058630497&doi=10.1039%2fc8md00431e&partnerID=40&md5=0d5fc7b87fd22fe3d97e639b850f07b4},

doi = {10.1039/c8md00431e},

issn = {20402503},

year  = {2018},

date = {2018-01-01},

journal = {MedChemComm},

volume = {9},

number = {12},

pages = {2017-2027},

publisher = {Royal Society of Chemistry},

abstract = {Novel goniofufurone (1) and 7-epi-goniofufurone (2) derivatives bearing a methoxy group at the C-5 and/or C-7 positions were prepared and their in vitro antitumour activity against some human tumour cell lines was evaluated. Some of the analogues displayed powerful antiproliferative effects against the studied tumour cells, but almost all of them were non-cytotoxic toward the normal cells (MRC-5). A SAR study reveals that the introduction of a methoxy group at the C-7 position may increase the antiproliferative effects of the analogues. The most active compounds are 7-O-methyl derivatives of goniofufurone (3) and 7-epi-(+)-goniofufurone (6), which exhibited 1177- and 451-fold higher potencies than the leads 1 and 2 toward the MDA-MB 231 cell line. At the same time, compound 3 is almost 1.5-fold more active than the commercial drug doxorubicin (DOX) against the same cell line. Flow cytometry data confirmed that the cytotoxic effects of these analogues are mediated by apoptosis, additionally revealing that these molecules induced changes in the K562 cell cycle distribution. © 2018 The Royal Society of Chemistry.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Radovanovic_2018_191,

title = {Diaquabis(2,2'-dipyridylamine)M(II) terephthalate dihydrates, M(II) = Ni, Co: Synthesis, crystal structures, thermal and magnetic properties},

author = {L. Radovanović and J. Rogan and D. Poleti and M. V. Rodić and Z. Jaglicic},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85044390339&doi=10.17344%2facsi.2017.3813&partnerID=40&md5=9ecea2e1cf13d3e99de662de5e65c2db},

doi = {10.17344/acsi.2017.3813},

issn = {13180207},

year  = {2018},

date = {2018-01-01},

journal = {Acta Chimica Slovenica},

volume = {65},

number = {1},

pages = {191-198},

publisher = {Slovensko Kemijsko Drustvo},

abstract = {Two new isostructural M(II) (M = Ni, Co) complexes with 2,2'-dipyridylamine (dipya) and dianion of terephthalic acid (H2tpht), [M(dipya)2(H2O)2](tpht) · 2H2O, have been synthesized by ligand exchange reaction and characterized by single-crystal X-ray diffraction, FTIR spectroscopy, TG/DSC analysis and magnetic measurements. The crystal structures of [M(dipya)2(H2O)2](tpht) · 2H2O consist of discrete complex units in which M(II) adopts deformed octahedral geometries. Two dipya ligands and two water molecules are coordinated to M(II) atom, tpht acts as a counter ion, while additional two water molecules remained uncoordinated. By numerous hydrogen bonds, all structural fragments are connected in three different chains which extend along [100], [010] and [001] directions, giving as a result a complex 3D network. The stabilization of 3D structure is accomplished by non-covalent face to face φ-φ interactions among pyridyl ring of dipya and benzene ring of tpht from adjacent chains. Towards the applied magnetic field, the both complexes exhibited almost perfect paramagnetic behavior. ©2018 Slovensko Kemijsko Drustvo. All Rights Reserved.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Radanovic_2018_157,

title = {2-Acetylpyrydine-aminoguanidine schiff base – Novel ligand salt and zinc(II) complex containing thiocyanate},

author = {M. M. Radanović and S. B. Novaković and L. S. Vojinović-Ješić and M. V. Rodić and V. M. Leovac},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85044332237&doi=10.2298%2fJSC170922116R&partnerID=40&md5=46640abcf407aafe879ebd2679d77900},

doi = {10.2298/JSC170922116R},

issn = {03525139},

year  = {2018},

date = {2018-01-01},

journal = {Journal of the Serbian Chemical Society},

volume = {83},

number = {2},

pages = {157-166},

publisher = {Serbian Chemical Society},

abstract = {A new salt of Schiff base of aminoguanidine and 2-acetylpyridine, and its zinc(II) complex were obtained and their physicochemical and structural properties studied. The reaction of an aqueous solution of the chloride ligand salt and NH4NCS resulted in formation of the dithiocyanate ligand salt, L·2HNCS, while the reaction of the obtained salt with zinc(II) acetate gave a neutral complex of the formula [ZnL(NCS)2]. In this complex, chelate ligand is coordinated in its neutral form, in a common tridentate NNN manner, via pyridine, azomethine and imino nitrogen atoms of the aminoguanidine fragment. This coordination mode results in formation of two strained five-membered metallocycles. Zinc(II) is situated in a distorted square-pyramidal environment of the tridentate ligand and one thiocyanate ion in the equatorial and the other thiocyanate ion in the apical position. The crystal structure of the ligand salt is stabilized by N–H…N and N–H…S interactions formed between the cationic and anionic species, while the three-dimensional crystal packing of the complex units is based on weak N–H…S interactions which involve the S acceptors from both NCS ligands. © 2018 Serbian Chemical Society. All Rights Reserved.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Zivkovic_2017_72,

title = {Anticancer potential of new steroidal thiazolidin-4-one derivatives. Mechanisms of cytotoxic action and effects on angiogenesis in vitro},

author = {M. B. Živković and I. Z. Matić and M. V. Rodić and I. T. Novaković and A. M. Krivokuća and D. M. Sladić and N. M. Krstić},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028028880&doi=10.1016%2fj.jsbmb.2017.07.031&partnerID=40&md5=2aa9b5c85d3424b2e6b9d36c09373238},

doi = {10.1016/j.jsbmb.2017.07.031},

issn = {09600760},

year  = {2017},

date = {2017-01-01},

journal = {Journal of Steroid Biochemistry and Molecular Biology},

volume = {174},

pages = {72-85},

publisher = {Elsevier Ltd},

abstract = {The synthesis and cytotoxic activities determination of new steroidal mono- and bis(thiazolidin-4-ones) 4a–f and 5a–f have been performed. Their anticancer action was also evaluated in comparison to previously synthesized and reported corresponding steroidal thiosemicarbazones. All compounds were obtained as stereoisomeric mixtures with different configuration (E or Z) in the hydrazone moiety at the C-3 position. After several consecutive crystallizations diastereomerically pure major (E)-isomers of mono-thiazolidin-4-ones were isolated. The structure and stereochemistry of 2,4-thiazolidinedione,2-[(17-oxoandrost-4-en-3-ylidene)hydrazone] were confirmed by X-ray analysis. A pathway for the formation of thiazolidin-4-one ring was proposed. The steroid thiazolidinone derivatives examined in this study exerted selective concentration-dependent cytotoxic activities on six tested malignant cell lines. Ten out of twelve examined compounds exhibited strong cytotoxic effects on K562 cells (IC50 values from 8.5 μM to 14.9 μM), eight on HeLa cells (IC50 values ranging from 8.9 μM to 15.1 μM) while against MDA-MB-361 cells six compouds exerted similar or even higher cytotoxic action (IC50 values from 12.7 μM to 25.6 μM) than cisplatin (21.5 μM) which served as a positive control. Eight of these ten compounds showed high selectivity in the cytotoxic action against HeLa and K562 cancer cell lines when compared with normal human fibroblasts MRC-5 and normal human PBMC. The study of mechanisms of the anticancer activity of the two selected compounds, mono- and bis(thiazolidin-4-one) derivatives of 19-norandrost-4-ene-3,17-dione 4a and 5a, revealed that both of these compounds induced apoptosis in HeLa cells through extrinsic and intrinsic signalling pathways. Treatment of EA.hy926 cells with sub-toxic concentrations of these compounds led to the inhibition of cell connecting and sprouting, and tube formation. The synthesized compounds exhibited poor antioxidant activity. © 2017 Elsevier Ltd},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Radanovic_2017_2870,

title = {Pyridoxylidene aminoguanidine and its copper(II) complexes–Syntheses, structure, and DFT calculations},

author = {M. M. Radanović and M. V. Rodić and S. Armaković and S. J. Armaković and L. S. Vojinović-Ješić and V. M. Leovac},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028535478&doi=10.1080%2f00958972.2017.1367388&partnerID=40&md5=8d3fa4d954b0c7e5446e051910b86522},

doi = {10.1080/00958972.2017.1367388},

issn = {00958972},

year  = {2017},

date = {2017-01-01},

journal = {Journal of Coordination Chemistry},

volume = {70},

number = {16},

pages = {2870-2887},

publisher = {Taylor and Francis Ltd.},

abstract = {Two nitrate salts of the well-known, and due to its significant biological activity very important, compound pyridoxylidene aminoguanidine (PLAG) were obtained in the form of single crystals. Thus this ligand is structurally characterized for the first time. In addition, the first data on the structure of a Schiff base of aminoguanidine with the active form of vitamin B6, i.e. pyridoxal-phosphate, of the formula PLPAG·HCl·2H2O, are presented. Two new square-pyramidal Cu(II) complexes of PLAG were synthesized and their physicochemical and structural properties analyzed. In these complexes, PLAG is coordinated as a zwitter-ion, in a tridentate ONN manner, via the oxygen atom of the deprotonated phenolic OH-group and nitrogen atoms of the azomethine and imino group of the aminoguanidine moiety. For the first time it was possible to make a comparative analysis of the structural properties of ligand salts and the coordinated ligand, so the effects of coordination could be unequivocally pointed out. Common fragments encountered in ligand structures were compared by half-normal probability plots. Density functional theory calculations have been conducted in order to gain insight into reactive properties of the investigated molecules. Molecular electrostatic potential, average local ionization energy surfaces, and Fukui functions have been calculated in order to obtain further information on the reactive properties. © 2017 Informa UK Limited, trading as Taylor & Francis Group.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Milosev_2017_943,

title = {Mannich bases of 1,2,4-triazole-3-thione containing adamantane moiety: Synthesis, preliminary anticancer evaluation, and molecular modeling studies},

author = {M. Z. Milošev and K. Jakovljević and M. D. Joksović and T. Stanojković and I. Z. Matić and M. Perović and V. Tešić and S. Kanazir and M. Mladenović and M. V. Rodić and V. M. Leovac and S. Trifunović and V. Marković},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019213707&doi=10.1111%2fcbdd.12920&partnerID=40&md5=1df7c645b5c49ccbb09a67ce39dc3c10},

doi = {10.1111/cbdd.12920},

issn = {17470277},

year  = {2017},

date = {2017-01-01},

journal = {Chemical Biology and Drug Design},

volume = {89},

number = {6},

pages = {943-952},

publisher = {Blackwell Publishing Ltd},

abstract = {A series of 18 novel N-Mannich bases derived from 5-adamantyl-1,2,4-triazole-3-thione was synthesized and characterized using NMR spectroscopy and X-ray diffraction technique. All derivatives were evaluated for their anticancer potential against four human cancer cell lines. Several tested compounds exerted good cytotoxic activities on K562 and HL-60 cell lines, along with pronounced selectivity, showing lower cytotoxicity against normal fibroblasts MRC-5 compared to cancer cells. The effects of compounds 5b, 5e, and 5j on the cell cycle were investigated by flow cytometric analysis. It was found that these compounds cause the accumulation of cells in the subG1 and G1 phases of the cell cycle and induce caspase-dependent apoptosis, while the anti-angiogenic effects of 5b, 5e, and 5j have been confirmed in EA.hy926 cells using a tube formation assay. Further, the interaction of Bax protein with compound 5b was investigated by means of molecular modeling, applying the combined molecular docking/molecular dynamics approach. © 2016 John Wiley & Sons A/S.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Radovanovic_2017_1247,

title = {A terephthalate-bridged two-dimensional heteronuclear Cu(II)-Mn(II) complex with a terminal 2,2′-dipyridylamine ligand},

author = {L. Radovanović and J. Rogan and D. Poleti and M. V. Rodić and Z. Jagličić},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85037622456&doi=10.2298%2fJSC170425086R&partnerID=40&md5=0e6cab51a18487ffa34bb4278c65d525},

doi = {10.2298/JSC170425086R},

issn = {03525139},

year  = {2017},

date = {2017-01-01},

journal = {Journal of the Serbian Chemical Society},

volume = {82},

number = {11},

pages = {1247-1258},

publisher = {Serbian Chemical Society},

abstract = {A terephthalate-bridged heteronuclear Cu(II)-Mn(II) complex [Cu2Mn(dipya)2(tpht)3]n, I, where dipya is 2,2-dipyridylamine and tpht is the anion of 1,4-benzenedicarboxylic (terephthalic, H2tpht) acid was synthesized under hydrothermal conditions. The obtained complex I was characterized by a single-crystal X-ray diffraction, FTIR spectroscopy, TG/DSC analysis and magnetic measurements. The Cu(II) and Mn(II) metal centers adopt distorted octahedral geometry and they are linked by bridging tpht ligands. Two crystallographically different tpht anions are coordinated as tridentate and hexadentate ligands forming two-dimensional layers. The layers are interconnected by hydrogen bonds and additionally stabilized by non-covalent C-H⋯π interactions. The measurements of magnetic susceptibility proved that I is an almost perfect paramagnet.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Djordjevic_2017_825,

title = {Synthesis, structures and electronic properties of Co(III) complexes with 2-quinolinecarboxaldehyde thio- and selenosemicarbazone: A combined experimental and theoretical study},

author = {I. S. Djordjevic and J. Vukasinovic and T. R. Todorovic and N. R. Filipovic and M. V. Rodic and A. Lolic and G. Portalone and M. Zlatovic and S. Grubisic},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85029451534&doi=10.2298%2fJSC170412062D&partnerID=40&md5=05ad3a50388335504ee9d2747bd7df5b},

doi = {10.2298/JSC170412062D},

issn = {03525139},

year  = {2017},

date = {2017-01-01},

journal = {Journal of the Serbian Chemical Society},

volume = {82},

number = {7-8},

pages = {825-839},

publisher = {Serbian Chemical Society},

abstract = {Cobalt(III) complexes derived from thio- and selenosemicarbazone ligands have been studied to elucidate the nature and consequences of S to Se substitution on their possible biological activity. Solid state structures of cobalt(III) complexes with bis-tridentate coordinated 2-quinolinecarboxaldehyde thio- and selenosemicarbazone were determined by single crystal X-ray diffraction analysis. The complexes were also characterized by spectroscopic methods and cyclic voltammetry. Electronic properties of the complexes were studied using DFT and TD-DFT methods. Finally, evident in vitro antioxidant activity of the complexes was demonstrated.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Filipovic_2017_2910,

title = {Co(III) complexes of (1,3-selenazol-2-yl)hydrazones and their sulphur analogues},

author = {N. R. Filipović and H. Elshaflu and S. Grubišić and L. S. Jovanović and M. Rodić and I. Novaković and A. Malešević and I. S. Djordjević and H. Li and N. Šojić and A. Marinković and T. R. Todorović},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014202888&doi=10.1039%2fc6dt04785h&partnerID=40&md5=756758492c611104b2f1e9c381e500c6},

doi = {10.1039/c6dt04785h},

issn = {14779226},

year  = {2017},

date = {2017-01-01},

journal = {Dalton Transactions},

volume = {46},

number = {9},

pages = {2910-2924},

publisher = {Royal Society of Chemistry},

abstract = {The first Co(iii) complexes with (1,3-selenazol-2-yl)hydrazones as an unexplored class of ligands were prepared and characterized by NMR spectroscopy and X-ray diffraction analysis. The novel ligands act as NNN tridentate chelators forming octahedral Co(iii) complexes. The impact of structural changes on ligands' periphery as well as that of isosteric replacement of sulphur with selenium on the electrochemical and electronic absorption features of complexes are explored. To support the experimental data, density functional theory (DFT) calculations were also conducted. Theoretical NMR chemical shifts, the relative energies and natural bond orbital (NBO) analysis are calculated within the DFT approach, while the singlet excited state energies and HOMO-LUMO energy gap were calculated with time-dependent density functional theory (TD-DFT). The electrophilic f- and nucleophilic f+ Fukui functions are well adapted to find the electrophile and nucleophile centres in the molecules. Both (1,3-selenazol-2-yl)- and (1,3-thiazol-2-yl)hydrazone Co(iii) complexes showed potent antimicrobial and antioxidant activity. A significant difference among them was a smaller cytotoxicity of selenium compounds. © The Royal Society of Chemistry.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Francuz_2017_13,

title = {Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position},

author = {J. Francuz and I. Kovačević and M. Popsavin and G. Benedeković and B. Srećo Zelenović and V. Kojić and D. Jakimov and L. Aleksić and G. Bogdanović and T. Srdić-Rajić and E. Lončar and M. V. Rodić and V. Divjaković and V. Popsavin},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85010310557&doi=10.1016%2fj.ejmech.2017.01.024&partnerID=40&md5=22522b859c719f275116667c02d6c987},

doi = {10.1016/j.ejmech.2017.01.024},

issn = {02235234},

year  = {2017},

date = {2017-01-01},

journal = {European Journal of Medicinal Chemistry},

volume = {128},

pages = {13-24},

publisher = {Elsevier Masson s.r.l.},

abstract = {A series of new antitumour lactones containing the [3.3.0] bicyclic furano-lactone core and the halogen or azido group at the C-7 position have been designed, synthesized, and evaluated for their in vitro antitumour activity against a panel of human tumour cell lines. Some of the analogues displayed powerful antiproliferative effects to certain human tumour cells, but all of them were devoid of any cytotoxicity towards the normal foetal lung fibroblasts (MRC-5). A SAR study reveals the structural features of these lactones that may affect their antiproliferative activity. These are: the nature of substituent present at the C-7 position, stereochemistry at the C-7 position, the absence of phenyl group at the C-7 position. Flow cytometry data indicate that the cytotoxic effects of the synthesized analogues in a culture of K562 cells are mediated by apoptosis, additionally revealing that these molecules induced changes in cell cycle distribution of these cells. Results of Western blot analysis suggested that the most of synthesized compounds induce apoptosis in K562 cells in caspase-dependent way. © 2017 Elsevier Masson SAS},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Elshaflu_2016_3354,

title = {Co(III) complex with (E)-2-(2-(pyridine-2-ylmethylene)hydrazinyl)-4-(4-tolyl)-1,3-thiazole: structure and activity against 2-D and 3-D cancer cell models},

author = {H. Elshaflu and S. Bjelogrlić and C. D. Muller and T. R. Todorović and M. Rodić and A. Marinković and N. R. Filipović},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988615513&doi=10.1080%2f00958972.2016.1232404&partnerID=40&md5=9b1033b05a2d35dc107d3185d42c1577},

doi = {10.1080/00958972.2016.1232404},

issn = {00958972},

year  = {2016},

date = {2016-01-01},

journal = {Journal of Coordination Chemistry},

volume = {69},

number = {22},

pages = {3354-3366},

publisher = {Taylor and Francis Ltd.},

abstract = {Co(III) complex with a 2-hydrazonylthiazole ligand was synthesized and characterized by single-crystal X-ray diffraction. In the inner sphere of the complex, two monoionic ligands are coordinated tridentately forming octahedral geometry around Co(III). Activity of the complex was investigated on MCF-7 breast cancer cell line, with cisplatin (CDDP) as a reference compound. Results showed that after 24-h incubation, Co(III) complex revealed stronger cytotoxic activity compared to CDDP. Treatment of MCF-7 3-D cell model with the complex at 10 μM concentration achieved complete suppression of spheroid growth in almost the same extent as at 100 μM. In combination treatments on MCF-7 spheroids, the complex acted synergistically with CDDP, while additive interaction type was achieved when the complex was applied together with paclitaxel. © 2016 Informa UK Limited, trading as Taylor & Francis Group.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Radovanovic_2016_18,

title = {Polymeric zinc complexes with 2,2′-dipyridylamine and different benzenepolycarboxylato ligands: Synthesis, structure, characterization and antimicrobial activity},

author = {L. Radovanović and J. Rogan and D. Poleti and M. Milutinović and M. V. Rodić},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84962917528&doi=10.1016%2fj.poly.2016.03.054&partnerID=40&md5=8d489083d2e4ec75f14715e0d9d0c85b},

doi = {10.1016/j.poly.2016.03.054},

issn = {02775387},

year  = {2016},

date = {2016-01-01},

journal = {Polyhedron},

volume = {112},

pages = {18-26},

publisher = {Elsevier Ltd},

abstract = {A series of new zinc complexes containing the 2,2′-dipyridylamine (dipya) ligand and anions of four benzenepolycarboxylic (BPC) acids, namely phthalic (H2pht), isophthalic (H2ipht), terephthalic (H2tpht) and pyromellitic (H4pyr), have been synthesized by ligand exchange reactions. The complexes were characterized based on elemental analysis, FTIR spectroscopy and thermal (TG/DSC) analysis. The complexes were found to have the formulae [Zn(dipya)(pht)] (1), [Zn(dipya)(ipht)]n (2), [Zn(dipya)(tpht)]·H2On (3) and [Zn2(dipya)2(pyr)] (4). Compounds 2 and 3 have been obtained as single crystals and their crystal structures were determined from X-ray diffraction data. In both structures the coordination number of the Zn atoms is five and they are linked by bridging BPC ligands. In 2, the ipht ligand is coordinated in a tridentate manner via chelate and monodentate COO groups, whereas two crystallographically different tpht ligands in 3 are coordinated as bis-chelate and bis-monodentate ligands, respectively. These combined modes of ipht and tpht anions resulted in zigzag chains of 2 and 3. Two-dimensional pseudo-layers in 2 and a three-dimensional network in 3 are governed by hydrogen bonds and C-H⋯O interactions which are formed between the zigzag chains, and by additional C-H⋯π interactions in 3. The antimicrobial activity of complexes 1-4 was screened in vitro against some Gram-positive bacteria (Bacillus subtilis, Enterococcus faecalis, Listeria monocytogenes and Staphylococcus aureus), some Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa and Salmonella enteritidis) and yeast Candida albicans. Complex 2 showed the most potent inhibitory effect against the tested microorganisms. © 2016 Elsevier Ltd. All rights reserved.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Rodic_2016_75,

title = {Synthesis, characterization, cytotoxicity and antiangiogenic activity of copper(II) complexes with 1-adamantoyl hydrazone bearing pyridine rings},

author = {M. V. Rodić and V. M. Leovac and L. S. Jovanović and V. Spasojević and M. D. Joksović and T. Stanojković and I. Z. Matić and L. S. Vojinović-Ješić and V. Marković},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84962278744&doi=10.1016%2fj.ejmech.2016.03.003&partnerID=40&md5=e4732fabb81465a66bf9c0ee64f3f6a1},

doi = {10.1016/j.ejmech.2016.03.003},

issn = {02235234},

year  = {2016},

date = {2016-01-01},

journal = {European Journal of Medicinal Chemistry},

volume = {115},

pages = {75-81},

publisher = {Elsevier Masson SAS},

abstract = {Three novel copper complexes with tridentate N2O ligand di(2-pyridil) ketone 1-adamantoyl hydrazone (Addpy) of the formula [CuII2CuI2(Addpy)2Br2(μ-Br4)] (1), catena-poly[CuCl(μ-Addpy)(μ-Cl)CuCl2]n (2) and [Cu(Addpy)(NCS)2] (3) were synthesized. Complexes are characterized by X-ray crystallography, spectral (UV-Vis, FTIR), electrochemical (CV) analyses, and magnetochemical measurements. Investigation of anticancer potential of Cu(II) complexes, mode of cell death, apoptosis, and inhibition of angiogenesis were performed. All tested malignant cell lines (HeLa, LS174, A549, K562, and MDA-MB-231) showed high sensitivity to the examined Cu(II) complexes. It has been shown that the complexes induce apoptosis in the caspase 3-dependent manner, whereas the anti-angiogenic effects of 1, 2, and 3 have been confirmed in EA.hy926 cells using a tube formation assay. © 2016 Elsevier Masson SAS. All rights reserved.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Radovanovic_2016_46,

title = {Structural diversity of manganese(II) complexes containing 2,2′-dipyridylamine and benzenedicarboxylates. Conformational analysis of tere-, iso- and phthalate ions: An experimental and quantum chemical approach},

author = {L. Radovanović and J. Rogan and D. Poleti and M. V. Rodić and N. Begović},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84962826846&doi=10.1016%2fj.ica.2016.02.026&partnerID=40&md5=3dd3e2633643083b6818ebb2ff052307},

doi = {10.1016/j.ica.2016.02.026},

issn = {00201693},

year  = {2016},

date = {2016-01-01},

journal = {Inorganica Chimica Acta},

volume = {445},

pages = {46-56},

publisher = {Elsevier S.A.},

abstract = {Four novel manganese(II) complexes with 2,2′-dipyridylamine (dipya) and various benzenedicarboxylate, BDC, ligands as anions of phthalic (pht), isophthalic (ipht) and terephthalic (tpht) acids were hydrothermally synthesized, namely, [Mn(dipya)(pht)(H2O)]2 (1), [Mn(dipya)(ipht)]n (2), [Mn(dipya)2(tpht)]n (3), and [Mn(dipya)(H2O)4](tpht) (4). All complexes were characterized by single-crystal X-ray diffraction, TG/DSC analysis and IR spectroscopy. The obtained complexes display a plenty of different structural features, including geometry of central metal atoms, BDC coordination modes and crystal packing. The coordination numbers of Mn(II) are different: 5 (in 2), 6 (in 3 and 4) and 7 (in 1). 3D networks in 1–4 are determined by strong non-covalent interactions. A survey of the Cambridge Structural Database for BDC complexes was performed in order to analyze orientation of COO groups. The energies of various BDC conformers were calculated by the second order Møller–Plesset perturbation theory and three hybrid HF/DFT methods with 6-311G∗∗ basis set. To explain different behavior, BDC ions were also examined by Localized Molecular Orbital Energy Decomposition and Natural Bond Orbital analyses. Experimental and calculated geometries are in agreement, showing that tpht and ipht anions prefer the planar conformation, while in pht anions COO groups are inclined and make complementary angles relative to the aromatic rings. © 2016 Elsevier B.V.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Vojinovic-Jesic_2016_2069,

title = {Synthesis, characterization and thermal behavior of copper(II) complexes with pyridoxal thiosemi (PLTSC)- and S-methylisothiosemicarbazone (PLITSC)},

author = {L. S. Vojinović-Ješić and M. V. Rodić and B. Barta Holló and S. A. Ivković and V. M. Leovac and K. Mészáros Szécsényi},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84959235591&doi=10.1007%2fs10973-015-4891-7&partnerID=40&md5=c023b9e9835a70080c8ceacf9ac3ba76},

doi = {10.1007/s10973-015-4891-7},

issn = {13886150},

year  = {2016},

date = {2016-01-01},

journal = {Journal of Thermal Analysis and Calorimetry},

volume = {123},

number = {3},

pages = {2069-2079},

publisher = {Springer Netherlands},

abstract = {The syntheses of complexes of Cu(II) with biological active ligand, pyridoxal thiosemicarbazone (PLTSC) and its derivative, pyridoxal S-methylisothiosemicarbazone, are described. All coordination compounds were characterized by elemental analysis, molar conductivity and infrared spectra. The crystal and molecular structure of complexes [Cu(μ-PLTSC)(H2O)2](SO4)2·6H2O (2) and [Cu(μ-PLTSC)(H2O)2](SO4)2·2H2O (2a) is determined by single-crystal X-ray crystallography, too. The thermal decomposition of all the ligands and complexes was determined by simultaneous TG/DSC measurements. The decomposition mechanisms were compared and analyzed from the aspects of the relationships between the structures of the compounds and their thermal decomposition pattern. © 2015 Akadémiai Kiadó, Budapest, Hungary.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Smit_2016_387,

title = {Synthesis of Angularly Fused (Homo)triquinane-Type Hydantoins as Precursors of Bicyclic Prolines},

author = {B. Šmit and M. Rodić and R. Z. Pavlović},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955188563&doi=10.1055%2fs-0035-1561285&partnerID=40&md5=ce07db180c93c03dfd9967f104cf5595},

doi = {10.1055/s-0035-1561285},

issn = {00397881},

year  = {2016},

date = {2016-01-01},

journal = {Synthesis (Germany)},

volume = {48},

number = {3},

pages = {387-393},

publisher = {Georg Thieme Verlag},

abstract = {An efficient strategy for a four-step synthesis of angularly fused tricyclic hydantoins as suitable precursors of cis-fused bicyclic α-amino acids is developed by combining a highly diastereoselective Bucherer-Bergs reaction of 2-alkenylcycloalkanones and a regiospecific selenium-induced closure of pyrrolidine ring. This methodology was applied in a five-step synthesis of bicycloproline derivatives in high overall yield. The method could be used for the multigram preparation of free conformationally constrained bicyclic α-amino acids with two points of diversity (size of cycloalkyl ring and substituent at the pyrrolidine ring). © Georg Thieme Verlag Stuttgart · New York-Synthesis 2016.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Kovacevic_2016_594,

title = {Synthesis and antiproliferative activity of goniobutenolides A and B, 5-halogenated crassalactone D derivatives and the corresponding 7-epimers},

author = {I. Kovačević and M. Popsavin and G. Benedeković and V. Kojić and D. Jakimov and M. V. Rodić and T. Srdić-Rajić and G. Bogdanović and V. Divjaković and V. Popsavin},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84951299322&doi=10.1016%2fj.ejmech.2015.12.011&partnerID=40&md5=475d563d20816b686f5cea08b1a356b5},

doi = {10.1016/j.ejmech.2015.12.011},

issn = {02235234},

year  = {2016},

date = {2016-01-01},

journal = {European Journal of Medicinal Chemistry},

volume = {108},

pages = {594-604},

publisher = {Elsevier Masson SAS},

abstract = {A new synthesis of goniobutenolides A (1) and B (2) and the corresponding 7-epimers has been achieved starting from diacetone d-glucose. The key step of the synthesis is a new one-pot sequence that commenced with Z-selective Wittig (or Horner-Wadsworth-Emmons) olefination, followed by successive γ-lactonisation and β-elimination. The above-mentioned unsaturated lactones were then converted to the corresponding 5-halogenated crassalactone D derivatives by using the appropriate haloetherification protocol. The most of synthesized compounds exhibited potent cytotoxic activities against a panel of tumour cell lines. The main structural features responsible for their antitumour potency have been revealed by means of SAR analysis. Flow cytometry data suggested that cytotoxic effects of these compounds in the culture of K562 cells might be mediated by apoptosis, additionally revealing that these molecules induced changes in cell cycle distribution of these cells. Results of semi-quantitative Western blot analysis indicate that the most of synthesized compounds induce apoptosis in a caspase-dependent manner. © 2015 Elsevier Masson SAS.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Barta_Hollo_2016_5885,

title = {Coordination compounds of a hydrazone derivative with Co(III), Ni(II), Cu(II) and Zn(II): Synthesis, characterization, reactivity assessment and biological evaluation},

author = {B. Barta Holló and J. Magyari and S. Armaković and G. A. Bogdanović and M. V. Rodić and S. J. Armaković and J. Molnár and G. Spengler and V. M. Leovac and K. Meszaros Szecsenyi},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84979026146&doi=10.1039%2fc6nj00560h&partnerID=40&md5=9b5b5b49007b5b0c9b0f5d44082ebaf6},

doi = {10.1039/c6nj00560h},

issn = {11440546},

year  = {2016},

date = {2016-01-01},

journal = {New Journal of Chemistry},

volume = {40},

number = {7},

pages = {5885-5895},

publisher = {Royal Society of Chemistry},

abstract = {A new hydrazone-type ligand with a five N-donor set and its coordination compounds with Co(iii), Ni(ii), Cu(ii) and Zn(ii) metal centres were synthesized. The crystal and molecular structure of the Co(iii) complex was determined by X-ray structural analysis. All the compounds were characterized by elemental analysis, molar conductivity and FT-IR spectral data. The cobalt(iii) compound is a neutral binuclear complex formed by coordination of two, doubly deprotonated ligand anions as bridges between the Co(iii) centres. The metal centres are additionally connected by a peroxido bridge, which was observed for the first time in Co(iii) complexes with similar ligands. The other coordination compounds are mononuclear complexes wherein only one doubly deprotonated ligand is coordinated to the central ion in a tetradentate fashion. The structures were theoretically investigated employing density functional theory (DFT) calculations with B3LYP exchange-correlation functional and LACV3P+(d,p) basis sets for the coordination compounds and 6-31+G(d,p) basis set for the ligand. Molecular electrostatic potential (MEP) and average local ionization energy (ALIE) surfaces were calculated to study the reactive properties of the compounds. The thermal behaviour of the compounds was determined by simultaneous thermogravimetric-differential scanning calorimetric (TG-DSC) measurements and the results were correlated to the proposed structures and to calculated MEP/ALIE surfaces. The compounds were tested in vitro for antiproliferative effects on parental (L5178Y) mouse T-cell lymphoma cells, on L5178Y transfected with pHa ABCB1/A retrovirus and for reversal of multidrug resistance (MDR) in tumor cells by flow cytometry. The preliminary measurements showed that the cobalt(iii) compound was an effective inhibitor of the ABC transporter PGP drug efflux pump. The ligand was somewhat less effective, the zinc complex had a moderate inhibition activity, whereas the nickel(ii) and copper(ii) compounds were inactive. © 2016 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Vojinovic-Jesic_2016_526,

title = {Syntheses and characterization of 2-acetylpyridine-aminoguanidine and its copper(II) complexes: Crystallographic and antimicrobial study},

author = {L. S. Vojinović-Ješić and M. M. Radanović and M. V. Rodić and V. Živković-Radovanović and L. S. Jovanović and V. M. Leovac},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84978388851&doi=10.1016%2fj.poly.2016.06.032&partnerID=40&md5=605dc8ab8db106b71ecc2e1730057c57},

doi = {10.1016/j.poly.2016.06.032},

issn = {02775387},

year  = {2016},

date = {2016-01-01},

journal = {Polyhedron},

volume = {117},

pages = {526-534},

publisher = {Elsevier Ltd},

abstract = {The syntheses, physico-chemical and microbiological properties of the ligand, 2-acetylpyridine-aminoguanidine dihydrogensulfate monohydrate and its five complexes with Cu(II) are described. The compounds were characterized by single crystal X-ray crystallography. Common fragments encountered in some of the structures were compared by r.m.s. overlay calculations as well as half-normal probability plots. In these complexes the chelate ligand is coordinated in its neutral form in a tridentate N3-coordination mode, via pyridine, azomethine and imino nitrogen atoms of the aminoguanidine fragment. In these complexes the Cu(II) ion is situated in moderately or severely distorted square-pyramidal surroundings. The antimicrobial activity of the ligand and the complexes were examined against 6 selected bacterial and 3 fungal strains. © 2016 Elsevier Ltd},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Zivkovic_2016_34312,

title = {Synthesis, characterization and in vitro cytotoxic activities of new steroidal thiosemicarbazones and thiadiazolines},

author = {M. B. Živković and I. Z. Matić and M. V. Rodić and I. T. Novaković and D. M. Sladić and N. M. Krstić},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964664175&doi=10.1039%2fc6ra01516f&partnerID=40&md5=fc6918f956be5b967deda4c5bafeb942},

doi = {10.1039/c6ra01516f},

issn = {20462069},

year  = {2016},

date = {2016-01-01},

journal = {RSC Advances},

volume = {6},

number = {41},

pages = {34312-34333},

publisher = {Royal Society of Chemistry},

abstract = {A series of new steroidal mono- and bis(thiosemicarbazones) (2a-e and 3a-e) and corresponding mono- and bis(1,3,4-thiadiazolines) (4a-e and 5a-e) was synthesized, characterized and evaluated for their anticancer activity. Detailed NMR analysis of the mono- and bis(thiosemicarbazones) revealed the presence of two stereoisomers (Z and E) with different configurations in the hydrazone moiety at the C-3 position, where the substituents on the C(3)=N double bond in the main isomers adopted the E configuration. The configurations at C-3 and C-17 in thiadiazolines 4a-e and 5a-e were deduced by detailed NMR analysis as well as by the examination of Dreiding molecular models and X-ray analysis of 3-thiadiazoline 4a, which confirmed the structure and absolute configuration at C-3. The synthesized compounds were tested against six cancer cell lines (HeLa, K562, MDA-MB-361, MDA-MB-453, LS174 and A549), the normal human cell line MRC-5 and peripheral blood mononuclear cells (PBMC) isolated from healthy donors. The best activity was exhibited by 3-thiosemicarbazones 2a, 2b, 2c and 2e and 3,17-bis(thiadiazolines) 5a and 5d. Examination of the mechanisms of cytotoxicity on cervical adenocarcinoma HeLa cells revealed the pro-apoptotic action of these compounds, which triggered both extrinsic and intrinsic apoptotic pathways. These compounds also showed the ability to decrease angiogenesis in vitro. In addition, 3,17-bis(thiadiazolines) 5a and 5d showed high selectivity in anticancer activity against all the examined malignant cell lines. Compound 5a displayed prominent anticancer potential. The tested compounds showed poor antimicrobial activity. © The Royal Society of Chemistry 2016.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Vojinovic-Jesic_2015_196,

title = {Transition metal complexes with thiosemicarbazide-based ligands. Part 63. Syntheses, structures and physicochemical characterization of the first chromium(III) complexes with pyridoxal semi- and thiosemicarbazones},

author = {L. S. Vojinović-Ješić and L. S. Jovanović and V. M. Leovac and M. M. Radanović and M. V. Rodić and B. Barta Holló and K. Mészásaros Szécsényi and S. A. Ivković},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84942417836&doi=10.1016%2fj.poly.2015.09.017&partnerID=40&md5=21155677f7a514e7dd010485b4fa2833},

doi = {10.1016/j.poly.2015.09.017},

issn = {02775387},

year  = {2015},

date = {2015-01-01},

journal = {Polyhedron},

volume = {101},

pages = {196-205},

publisher = {Elsevier Ltd},

abstract = {With pyridoxal semi-/thiosemicarbazones (PLSC/PLTSC) ligands for the first time chromium complexes were obtained. In the reaction of ethanolic solution of Cr(NO3)3 and K3[Cr(NCS)6] and the ligands in mole ratio 1:1 or 1:2, the following complexes were formed: [Cr(PLSC)(PLSC-H)](NO3)2·H2O (1), K[Cr(PLSC-H)(NCS)3]·EtOH (2), [Cr(PLTSC)(PLTSC-H)](NO3)2·2H2O (3), [Cr(PLTSC)2](NO3)3 (4) and [Cr(PLTSC)(NCS)3]·2H2O (5). All the complexes have mer-octahedral structure which in the cases of the complexes 2, 4 and 5 was proved by single-crystal X-ray diffraction analysis. The Schiff bases coordinate in the usual tridentate ONX manner (X = O/S; PLSC/PLTSC). The pyridoxalic fragment is zwitter ion regardless of the form of the coordinated ligands: neutral (keto/thion) and monoanionic (enolic/thiolic). In addition to the above complexes, X-ray crystallography was used to characterize neutral and protonated forms of PLSC, i.e., PLSC·2H2O and PLSC·HNCS, the latter one being obtained as a by-product of the reaction of formation of the complex 2 using K3[Cr(NCS)6] and PLSC in the mole ratio 1:2. The X-ray analyses of these ligand forms have shown that in the case of PLSC·HNCS the ligators Ophenolic, Nazomethine, Oketo due to strong hydrogen O2-HN3 bond are placed in cis-position to each other (pro-binding conformation) which is not the case with PLSC·2H2O. The compounds are characterized thoroughly by also IR/UV-Vis spectral analyses, electrochemical and thermal methods. © 2015 Elsevier Ltd. All rights reserved.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Poleti_2015_110,

title = {Mixed-ligand MnII and CuII complexes with alternating 2,2'-bipyrimidine and terephthalate bridges},

author = {D. Poleti and J. Rogan and M. V. Rodić and L. Radovanović},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84922559772&doi=10.1107%2fS2053229614028113&partnerID=40&md5=c635225e2d35362c59aa238898508ec6},

doi = {10.1107/S2053229614028113},

issn = {20532296},

year  = {2015},

date = {2015-01-01},

journal = {Acta Crystallographica Section C: Structural Chemistry},

volume = {71},

number = {2},

pages = {110-115},

publisher = {International Union of Crystallography},

abstract = {The novel polymeric complexes catena-poly[[diaquamanganese(II)]-μ-2,2'-bipyrimidine-κ4 N1,N1':N3,N3'-[diaquamanganese(II)]-bis(μ-terephthalato-κ2 O1:O4)], [Mn2(C8H4O4)2(C8H6N4)(H2O)4] n , (I), and catena-poly[[[aquacopper(II)]-μ-aqua-μ-hydroxido-μ-terephthalato-κ2 O1:O1'-copper(II)-μ-aqua-μ-hydroxido-μ-terephthalato-κ2 O1:O1'-[aquacopper(II)]-μ-2,2'-bipyrimidine-κ4 N1,N1':N3,N3'] tetrahydrate], [Cu3(C8H4O4)2(OH)2(C8H6N4)(H2O)4]·4H2On , (II), containing bridging 2,2'-bipyrimidine (bpym) ligands coordinated as bis-chelates, have been prepared via a ligand-exchange reaction. In both cases, quite unusual coordination modes of the terephthalate (tpht2-) anions were found. In (I), two tpht2- anions acting as bis-monodentate ligands bridge the MnII centres in a parallel fashion. In (II), the tpht2- anions act as endo-bridges and connect two CuII centres in combination with additional aqua and hydroxide bridges. In this way, the binuclear [Mn2(tpht)2(bpym)(H2O)4] entity in (I) and the trinuclear [Cu3(tpht)2(OH)2(bpym)(H2O)4]·4H2O coordination entity in (II) build up one-dimensional polymeric chains along the b axis. In (I), the MnII cation lies on a twofold axis, whereas the four central C atoms of the bpym ligand are located on a mirror plane. In (II), the central CuII cation is also on a special position (site symmetry ). In the crystal structures, the packing of the chains is further strengthened by a system of hydrogen bonds [in both (I) and (II)] and weak face-to-face π-π interactions [in (I)], forming three-dimensional metal-organic frameworks. The MnII cation in (I) has a trigonally deformed octahedral geometry, whereas the CuII cations in (II) are in distorted octahedral environments. The CuII polyhedra are inclined relative to each other and share common edges. © 2015 International Union of Crystallography.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Dobricic_2015_1481,

title = {Synthesis, crystal structure and local anti-inflammatory activity of the L-phenylalanine methyl ester derivative of dexamethasone-derived cortienic acid},

author = {V. Dobricic and B. M. Francuski and V. Jacevic and M. V. Rodic and S. Vladimirov and O. Cudina and D. Francuski},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84957534849&doi=10.2298%2fJSC150505067D&partnerID=40&md5=43d98446fcf591e3401f4bb745fabc01},

doi = {10.2298/JSC150505067D},

issn = {03525139},

year  = {2015},

date = {2015-01-01},

journal = {Journal of the Serbian Chemical Society},

volume = {80},

number = {12},

pages = {1481-1488},

publisher = {Serbian Chemical Society},

abstract = {The L-phenylalanine methyl ester derivative of dexamethasonederived cortienic acid (DF) was synthesized and its crystal structure characterized by the X-ray diffraction method. The crystal system is orthorhombic with space group P212121 and cell constants a = 8.2969(3) Å},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Novkovic_2015_99577,

title = {Synthesis of endoperoxides by domino reactions of ketones and molecular oxygen},

author = {L. Novkovic and M. Trmcic and M. Rodic and F. Bihelovic and M. Zlatar and R. Matovic and R. N. Saicic},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84948440550&doi=10.1039%2fc5ra13476e&partnerID=40&md5=017296465f02cbcfb0fb69e797566b54},

doi = {10.1039/c5ra13476e},

issn = {20462069},

year  = {2015},

date = {2015-01-01},

journal = {RSC Advances},

volume = {5},

number = {120},

pages = {99577-99584},

publisher = {Royal Society of Chemistry},

abstract = {Domino reactions of ketones with molecular oxygen in the presence of potassium hydroxide and potassium t-butoxide afford cyclic hydroperoxy acetals (3,5-dihydroxy-1,2-dioxanes). Mixed endoperoxides can also be obtained in a three-component reaction of two ketones and oxygen. © 2015 The Royal Society of Chemistry.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Filipovic_2015_95191,

title = {Zn(II) complex with 2-quinolinecarboxaldehyde selenosemicarbazone: Synthesis, structure, interaction studies with DNA/HSA, molecular docking and caspase-8 and -9 independent apoptose induction},

author = {N. R. Filipović and S. Bjelogrlić and A. Marinković and T. Ž. Verbić and I. N. Cvijetić and M. Senćanski and M. Rodić and M. Vujčić and D. Sladić and Z. Striković and T. R. Todorović and C. D. Muller},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84946944475&doi=10.1039%2fc5ra19849f&partnerID=40&md5=f97cfab66f4bfa8751cd5bf902bc95d2},

doi = {10.1039/c5ra19849f},

issn = {20462069},

year  = {2015},

date = {2015-01-01},

journal = {RSC Advances},

volume = {5},

number = {115},

pages = {95191-95211},

publisher = {Royal Society of Chemistry},

abstract = {A new Zn(ii)-based potential chemotherapeutic agent was synthesized from the ligand 2-quinolinecarboxaldehyde selenosemicarbazone (Hqasesc). Single crystal X-ray diffraction analysis showed that the Zn(ii) complex consists of a cation [Zn(Hqasesc)2]2+, two perchlorate anions and one ethanol solvent molecule. The interaction of calf thymus (CT) DNA and human serum albumin (HSA) with the Zn(ii) complex was explored using absorption and emission spectral methods, and also has been supported by molecular docking studies. The complex has more affinity to minor DNA groove than major, with no significant intercalation. The HSA interaction studies of the complex revealed the quenching of the intrinsic fluorescence of the HSA through a static quenching mechanism. The antitumor activity of the ligand and the complex against pancreatic adenocarcinoma cell line (AsPC-1) and acute monocytic leukemia (THP-1) cells was evaluated. Both compounds are strong concentration-dependent apoptosis inducers in THP-1 cells. While Hqasesc in AsPC-1 cells induces apoptosis only at the highest concentration, treatment with the Zn complex shows a concentration-dependent apoptotic response, where the treated cells are arrested in the G1-to-S phase accompanied with extensive activation of caspase-8 and -9. These results indicate that the ligand and Zn(ii) complex display cell phenotype specific activity. © 2015 The Royal Society of Chemistry.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ivkovic_2015_269,

title = {Transition metal complexes with thiosemicarbazide-based ligands. Part 61. Comparative analysis of structural properties of the pyridoxal thiosemicarbazone ligands. Crystal structure of PLTSC·HCl·2H2O and its complex [Fe(PLTSC)Cl2(H2O)]Cl},

author = {S. A. Ivković and L. S. Vojinović-Ješić and V. M. Leovac and M. V. Rodić and S. B. Novaković and G. A. Bogdanović},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84939888010&doi=10.1007%2fs11224-014-0491-6&partnerID=40&md5=fdb0c583fb0ec5a62bb427aa42a41707},

doi = {10.1007/s11224-014-0491-6},

issn = {10400400},

year  = {2015},

date = {2015-01-01},

journal = {Structural Chemistry},

volume = {26},

number = {1},

pages = {269-277},

publisher = {Springer New York LLC},

abstract = {A novel pyridoxal thiosemicarbazone (PLTSC) compound, exhibiting ligating properties, of the formula PLTSC·HCl·2H2O (1) was synthesized and characterized by X-ray analysis. The PLTSC ligand 1 displays significantly different conformation in comparison to the five previously reported compounds of this type. The structural properties of six PLTSC ligands in different conformations were compared in order to establish the structural differences and understand the factors that facilitate particular conformations. The analysis indicated great structural flexibility of the PLTSC ligands. The PLTSC ligand 1 is essentially a planar molecule with the r.m.s deviation of all non-H atoms equal to 0.06 Å. Consequently, the molecules of 1 form a layered three-dimensional structure which is stabilized by a variety of hydrogen bonds: O-H⋯O, O-H⋯N, O-H⋯Cl, O-H⋯S, N-H⋯O, N-H⋯N, N-H⋯Cl, N-H⋯S. In addition, the crystal structure of the Fe(III) complex with the ligand 1 of the formula [Fe(PLTSC)Cl2(H2O)]Cl was resolved by single-crystal X-ray analysis and structural properties of this octahedral complex were discussed and compared to those of uncoordinated PLTSC ligand. © 2014 Springer Science+Business Media New York.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Leovac_2015_882,

title = {Transition metal complexes with 1-adamantoyl hydrazones - Cytotoxic copper(II) complexes of tri- and tetradentate pyridine chelators containing an adamantane ring system},

author = {V. M. Leovac and M. V. Rodic and L. S. Jovanovic and M. D. Joksovic and T. Stanojkovic and M. Vujčic and D. Sladic and V. Markovic and L. S. Vojinovic-Ješic},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84922475134&doi=10.1002%2fejic.201403050&partnerID=40&md5=8079ef0231bc5e75e55576d8b4f2eed8},

doi = {10.1002/ejic.201403050},

issn = {14341948},

year  = {2015},

date = {2015-01-01},

journal = {European Journal of Inorganic Chemistry},

volume = {2015},

number = {5},

pages = {882-895},

publisher = {Wiley-VCH Verlag},

abstract = {Five pentacoordinate copper(II) complexes with 2-acetylpyridine or di(2-pyridyl) ketone 1-adamantoyl hydrazone ligands (Adpy and Addpy, respectively) of the formulae [CuCl2(Adpy)] (1), [Cu2(μ-Cl)2(Adpy-H)2] (2), [Cu(NCS)2(Adpy)] (3), [Cu2(μ-Cl)2(Addpy-H)2] (4), and [Cu2(NCS)2(μ-Addpy-H)2] (5) were synthesized and characterized by spectral, electrochemical, and X-ray structural analysis. Flow cytometry and morphological analysis confirmed that the copper(II) complexes 2 and 5 induced accumulation of a sub-G1 phase population, and fluorescence microscopy indicated the presence of large cells in apoptosis. The interaction of the copper(II) complexes with calf thymus DNA (CT-DNA) was monitored by changes in their UV/Vis spectra. The observed intrinsic binding constants for 2 and 5 (Kb = 1.77-×-106 and 3.58-×-106 M-1, respectively) together with ethidium displacement fluorescence experiments indicate intercalative binding. Complexes 2 and 5 showed nuclease activity against pUC19 plasmid DNA. Five CuII complexes with 2-acetylpyridine or di(2-pyridyl) ketone 1-adamantoyl hydrazones have been prepared and physicochemically characterized. All of the tested complexes exhibit strong cytotoxic activity and induce apoptosis as the primary method of cell death. An intercalative mode of interaction with DNA was determined, and pronounced double-strand cleavage of supercoiled DNA was observed. Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Jaso_2015_20,

title = {Biocompatible fibers from thermoplastic polyurethane reinforced with polylactic acid microfibers},

author = {V. Jašo and M. V. Rodić and Z. S. Petrović},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84919905338&doi=10.1016%2fj.eurpolymj.2014.11.041&partnerID=40&md5=5063525f23783707630db638ef1c73fd},

doi = {10.1016/j.eurpolymj.2014.11.041},

issn = {00143057},

year  = {2015},

date = {2015-01-01},

journal = {European Polymer Journal},

volume = {63},

pages = {20-28},

publisher = {Elsevier Ltd},

abstract = {Fiber-reinforced composites were prepared by extrusion of biphasic thermoplastic polyurethane/polylactic acid blends and the morphology was studied by electron microscopy. Reinforcing effect of in-situ formed PLA microfibers on polyurethane matrix was found. Polylactic acid (PLA) content was varied from 10 to 40 wt% resulting in reinforced polyurethane matrices with fibrils of 200-800 nm. Highly amorphous PLA fibrils crystallized when heated above glass transition, resulting in storage modulus increase as observed by dynamic mechanical analysis. Polyurethane (TPU) fibers reinforced with PLA microfibers had improved tensile strength and retained relatively high elongation, but elastic recovery decreased and hysteresis increased relative to the neat TPU. Orientation of fibers induced by cold drawing increased tensile strength and elastic modulus. © 2014 Elsevier Ltd. All rights reserved.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Vojinovic-Jesic_2014_90,

title = {Syntheses, structures and spectral characterization of copper(II) and dioxidovanadium(V) complexes with salicylidene-aminoguanidine},

author = {L. S. Vojinović-Ješić and M. M. Radanović and M. V. Rodić and L. S. Jovanović and V. I. Češljević and M. D. Joksović},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84905500536&doi=10.1016%2fj.poly.2014.02.003&partnerID=40&md5=f61b40677802bfe7d7237881a3b6c6d0},

doi = {10.1016/j.poly.2014.02.003},

issn = {02775387},

year  = {2014},

date = {2014-01-01},

journal = {Polyhedron},

volume = {80},

pages = {90-96},

publisher = {Elsevier Ltd},

abstract = {The reaction of SalAG·HNO3 with Cu(OAc) 2·H2O in the presence of NH4SCN and NaN3 resulted in formation of the complexes [Cu(SalAG-H)NCS] and [Cu2(SalAG-H)2(N3)2], respectively, while this ligand with NH4VO3 produced [VO 2(SalAG-H)]. In the complexes, the ligand is coordinated as a monoanion, in a tridentate ONN mode, via phenolic oxygen atom and nitrogen atoms of azomethine and imino groups of the aminoguanidine fragment. The ligand and its complexes were characterized by elemental analysis, IR, NMR and UV-Vis spectroscopy, and single crystal X-ray diffraction analysis. Cyclic voltammetric studies of the ligand and copper(II) complexes in DMF show that electron transfers are complicated by following chemical reactions. © 2014 Elsevier Ltd. All rights reserved.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Dordevic_2014_234,

title = {Synthesis, structure and biological activities of Pd(II) and Pt(II) complexes with 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone},

author = {M. M. Dordević and D. A. Jeremić and M. V. Rodić and V. S. Simić and I. D. Brčeski and V. M. Leovac},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84888360858&doi=10.1016%2fj.poly.2013.10.029&partnerID=40&md5=21f7cceadc6986183c0f4ff3fb3b6841},

doi = {10.1016/j.poly.2013.10.029},

issn = {02775387},

year  = {2014},

date = {2014-01-01},

journal = {Polyhedron},

volume = {68},

pages = {234-240},

abstract = {The reaction of an ethanolic solution of the newly synthesized 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone (HL) with aqueous solutions of K2[MCl4] (M = Pd(II), Pt(II)) resulted in neutral complexes of the general formulae [M(L)Cl]. These complexes have a square-planar structure that was achieved by tridentate PNO coordination of the monoprotonated Schiff base and a chloride ligand. The ligand and its metal complexes were analyzed for their antimicrobial activity and their in vitro cytotoxicity in human larynx carcinoma cells (Hep-2) and non-cancerous human lung fibroblast cells (MRC-5). The platinum(II) complex shows cytotoxicity towards Hep-2 cells comparable to oxaliplatin and exhibited improved selectivity for cancer cells. The ligand and its complexes were characterized by elemental analysis, NMR and IR spectroscopy, and single crystal X-ray diffraction analysis. © 2013 Elsevier Ltd. All rights reserved.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Poleti_2014_637,

title = {Structural, spectral and thermal properties of 2-(2-pyridylamino)pyridinium trihydrogen pyromellitate},

author = {D. Poleti and J. Rogan and L. Radovanović and M. Rodić},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84903129234&doi=10.2298%2fJSC130706115P&partnerID=40&md5=b40c0e9394979d65195c25f784baf684},

doi = {10.2298/JSC130706115P},

issn = {03525139},

year  = {2014},

date = {2014-01-01},

journal = {Journal of the Serbian Chemical Society},

volume = {79},

number = {6},

pages = {637-648},

publisher = {Serbian Chemical Society},

abstract = {The title compound, (Hdipya)(H3pyr), where Hdipya is protonated 2,2'-dipyridilamine and H3pyr is the monoanion of pyromellitic acid (H4pyr), was obtained from a reaction mixture containing Zn(II) ions, dipya, Na4pyr (in the mole ratio 2:2:1) and HNO3. The products (micro- and single-crystalline) were characterized by X-ray structure determination, FT-IR spectroscopy and TG/DSC analysis. The most striking structural feature of (Hdipya)(H3pyr) are short inter- and extremely short intramolecular hydrogen bonds. These bonds mutually connect cations and anions making thin layers parallel to the crystallographic (223) plane. In addition, quite unusual, linear proton-bound polymeric H(H2pyr) -n were identified in the structure. The results of crystal structure determination are compared with FT-IR and TG/DSC data. The low position of the νas(COO) vibration at 1660 cm-1 is in accordance with strong hydrogen bonding. This value could be used as a measure of the C=O bond order, which was calculated to be 1.81. © 2014 SCS. All rights reserved.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hollo_2014_655,

title = {Crystal structure, thermal behavior, and microbiological activity of a thiosemicarbazide-type ligand and its cobalt complexes},

author = {B. Holló and M. V. Rodić and L. S. Vojinović-Ješić and V. Živković-Radovanović and G. Vučković and V. M. Leovac and K. M. Szécsényi},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899927596&doi=10.1007%2fs10973-013-3489-1&partnerID=40&md5=53528c35f5d342f7b5e9df4fd428965a},

doi = {10.1007/s10973-013-3489-1},

issn = {13886150},

year  = {2014},

date = {2014-01-01},

journal = {Journal of Thermal Analysis and Calorimetry},

volume = {116},

number = {2},

pages = {655-662},

publisher = {Kluwer Academic Publishers},

abstract = {The synthesis of a potentially bioactive mixed-valence Co III/CoII complex with 2-acetylpyridine S-methylisothiosemicarbazone (HL) ligand is described. The crystal and molecular structure of the formed [CoIIIL2][CoIICl 3 py]·Me2CO (I) compound (py stands for pyridine) is determined by single-crystal X-ray crystallography. It's thermal decomposition along with the decomposition of the ligand and six structurally related complexes with formulas [CoL2]NO3·MeOH (1), [CoL2]Br·MeOH (2), [CoL2]HSO4· MeOH (3), [CoL2]2[CoII(NCS)4] (4), [Co(HL)(L)]I2·2MeOH (5), and [Co(HL)(L)][Co IICl4]·MeOH (6) was determined by simultaneous TG/DSC measurements. The decomposition pattern is evaluated using TG/DTA-MS data. The results were related to the solvent/moisture content and the decomposition mechanism of the compounds. The antimicrobial activity of the ligand and of all the complexes was tested in vitro for selected gram-negative and gram-positive bacteria and fungi. The activity of the ligand against all tested bacteria is comparable with those obtained for standard antibiotics, while it is less active against fungi. Surprisingly, the activity of the complexes is very low. The low antimicrobial activity of the complexes may be in connection with their high thermodynamic and kinetic inertness in solution. The results are also supported by the relatively high thermal stability of the complexes. © 2013 Akadémiai Kiadó, Budapest, Hungary.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Leovac_2014_291,

title = {Transition metal complexes with thiosemicarbazide-based ligands. Part 60. Reactions of copper(II) bromide with pyridoxal S-methylisothiosemicarbazone (PLITSC). Crystal structure of [Cu(PLITSC-H)H2O]Br·H 2O},

author = {V. M. Leovac and L. S. Vojinović-Ješić and S. A. Ivković and M. V. Rodić and L. S. Jovanović and B. Holló and K. M. Szécsényi},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84896917209&doi=10.2298%2fJSC130622084L&partnerID=40&md5=a467400d954fe86519e4d7a4ac3a7a70},

doi = {10.2298/JSC130622084L},

issn = {03525139},

year  = {2014},

date = {2014-01-01},

journal = {Journal of the Serbian Chemical Society},

volume = {79},

number = {3},

pages = {291-302},

publisher = {Serbian Chemical Society},

abstract = {The synthesis and structural characterization of a square-planar copper(II) complex with pyridoxal S-methylisothiosemicarbazone (PLITSC) of the formula [Cu(PLITSC-H)H2O]Br·H2O (1) as the first Cu(II) complex with a monoanionic form of this ligand were described. Complex 1 together with two previously synthesized complexes [Cu(PLITSC)Br2] (2) and [Cu(PLITSC)-Br(MeOH)]Br (3) were characterized by elemental analysis, IR and electronic spectroscopy and by the methods of thermal analysis, conductometry and magnetochemistry. © 2014 Copyright SCS.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Markovic_2013_2127,

title = {Mechanistic investigation and DFT calculation of the new reaction between S-methylisothiosemicarbazide and methyl acetoacetate},

author = {V. Marković and S. Marković and A. Janićijević and M. V. Rodić and V. M. Leovac and N. Todorović and S. Trifunović and M. D. Joksović},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84889098809&doi=10.1007%2fs11224-013-0223-3&partnerID=40&md5=da3970a95b742cd0c758c034163816c5},

doi = {10.1007/s11224-013-0223-3},

issn = {10400400},

year  = {2013},

date = {2013-01-01},

journal = {Structural Chemistry},

volume = {24},

number = {6},

pages = {2127-2136},

abstract = {A study on the synthesis and mechanistical aspects of formation of 3-methyl-5-oxo-3-pyrazolin-1-carboxamide (MOPC) starting from S-methylisothiosemicarbazide hydrogen iodide and methyl acetoacetate was performed. In the alkaline aqueous solution, the intermediate methyl acetoacetate S-methylisothiosemicarbazone undergoes substitution of CH 3S- anion by hydroxide anion, cyclization, carbanion formation, and elimination of methanol, thus yielding corresponding Na-enolate salt of pyrazol-5-one derivative. The structure of the compound obtained after protonation of the formed enolate salt was determined by means of spectroscopic techniques and single-crystal X-ray diffraction analysis. The mechanism of conversion of methyl acetoacetate S-methylisothiosemicarbazone into MOPC was investigated by means of the B3LYP functional, and it was found that the reaction is thermodynamically controlled. © 2013 Springer Science+Business Media New York.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Novakovic_2013_o1638,

title = {4-Dichloromethyl-4-methyl-5-(nitromethyl)cyclohex-2-enone},

author = {S. B. Novaković and M. V. Rodić and Z. K. Jaćimović and Z. Ratković and S. Sukdolak},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84887245605&doi=10.1107%2fS1600536813027517&partnerID=40&md5=1c25915352b7314b5cddfb20227b5269},

doi = {10.1107/S1600536813027517},

issn = {16005368},

year  = {2013},

date = {2013-01-01},

journal = {Acta Crystallographica Section E: Structure Reports Online},

volume = {69},

number = {11},

pages = {o1638},

abstract = {In the title compound, C9H11Cl2NO 3, the six-membered ring adopts a screw-chair conformation. In the crystal, two different C - H⋯O hydrogen bonds involving the same acceptor atom connect the molecules into a chain extending along the c-axis direction.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Novakovic_2013_761,

title = {(E)-4-[(2-Carbamoylhydrazinylidene)methyl]-3-hydroxy-5-hydroxymethyl-2- methylpyridin-1-ium nitrate},

author = {S. B. Novaković and G. A. Bogdanović and V. M. Leovac and M. V. Rodić and L. S. Vojinović-Ješić and S. Ivković},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84880179167&doi=10.1107%2fS0108270113013929&partnerID=40&md5=913080294327486312fb0472b11bdc29},

doi = {10.1107/S0108270113013929},

issn = {01082701},

year  = {2013},

date = {2013-01-01},

journal = {Acta Crystallographica Section C: Crystal Structure Communications},

volume = {69},

number = {7},

pages = {761-764},

abstract = {The title compound, C9H13N4O3 +·NO3 -, is the first structurally characterized Schiff base derived from semicarbazide and pyridoxal. Unusually for an unsubstituted semicarbazone, the compound adopts a syn conformation, in which the carbonyl O atom is in a cis disposition relative to the azomethine N atom. This arrangement is supported by a pair of hydrogen bonds between the organic cation and the nitrate anion. The cation is essentially planar, with only a hydroxymethyl O atom deviating significantly from the mean plane of the remaining atoms (r.m.s. deviation of the remaining non-H atoms = 0.01 Å). The molecules are linked into flat layers by N - H⋯O and C - H⋯O hydrogen bonds. O - H⋯O hydrogen bonds involving the hydroxymethyl group as a donor interconnect the layers into a three-dimensional structure. © 2013 International Union of Crystallography.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hollo_2013_2193,

title = {Cation- and/or anion-directed reaction routes. Could the desolvation pattern of isostructural coordination compounds be related to their molecular structure?},

author = {B. Holló and M. V. Rodić and O. Bera and M. Jovičić and V. M. Leovac and Z. D. Tomić and K. Mészáros Szécsényi},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84889082131&doi=10.1007%2fs11224-013-0270-9&partnerID=40&md5=cd58f28edf64c85d27dce37adb8f2d72},

doi = {10.1007/s11224-013-0270-9},

issn = {10400400},

year  = {2013},

date = {2013-01-01},

journal = {Structural Chemistry},

volume = {24},

number = {6},

pages = {2193-2201},

publisher = {Springer New York LLC},

abstract = {The crystal and molecular structure of [Cu(ampf)(ClO 4 )(MeOH) 2 ]ClO 4 , (1)},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Lalovic_2013_1161,

title = {Dioxidovanadium(V) complexes with pyridoxal aminoguanidine derivative: Synthesis and spectral and structural characterization},

author = {M. M. Lalović and V. M. Leovac and L. S. VOJINOVIć-JEŠIć and M. V. Rodić and L. S. Jovanović and V. I. Češljević},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84884273674&doi=10.2298%2fJSC130326038L&partnerID=40&md5=a73630176dd50f386c03ceac80703308},

doi = {10.2298/JSC130326038L},

issn = {03525139},

year  = {2013},

date = {2013-01-01},

journal = {Journal of the Serbian Chemical Society},

volume = {78},

number = {8},

pages = {1161-1170},

publisher = {Serbian Chemical Society},

abstract = {Three square-pyramidal complexes of dioxidovanadium(V) with [(3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridyl)methylene]aminoguanidine (PLAG), of the formulas NH$_4$[VO$_2$(PLAG$-$2H)]H$_2$O (1), VO2(PLAG-H) (2) and K[VO2(PLAG-2H)]H2O (3) were synthesized and characterized by IR and electronic spectra, and in case of 1 and 3 by X-ray crystallography as well. The reaction of aqueous ammoniacal solution of NH4VO3 and PLAG resulted in formation of 1, which in MeOH undergoes spontaneous transformation into 2, which, in turn, in the reaction with KOH transforms into 3. In these complexes, PLAG is coordinated in a common tridentate ONN mode, via the phenoxide oxygen atom and the nitrogen atoms of the azomethine and imino groups of the aminoguanidine fragment. In all previously characterized complexes, PLAG was coordinated in the neutral form. However, here it was proven that this ligand could be coordinated in both mono- (2) and doublydeprotonated forms (1 and 3) as well. © 2013 (CC) SCS.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Lalovic_2012_4217,

title = {Syntheses, crystal structures, and electrochemical characterizations of two octahedral iron(III) complexes with Schiff base of pyridoxal and aminoguanidine},

author = {M. M. Lalović and L. S. Jovanović and L. S. Vojinović-Ješić and V. M. Leovac and V. I. Češljević and M. V. Rodić and V. Divjaković},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84871242838&doi=10.1080%2f00958972.2012.737916&partnerID=40&md5=1a96750f5711581f749b751ae6324d41},

doi = {10.1080/00958972.2012.737916},

issn = {00958972},

year  = {2012},

date = {2012-01-01},

journal = {Journal of Coordination Chemistry},

volume = {65},

number = {23},

pages = {4217-4229},

abstract = {This article presents the synthesis, physico-chemical, in particular voltammetric, characteristics of two iron(III) complexes with pyridoxal aminoguanidine (PLAG), [Fe(PLAG)Cl2(H2O)]Cl (1) and [Fe(PLAG)2](NO3)3 (2). As expected, the zwitterion of the chelate ligand is coordinated tridentate through oxygen of phenol and nitrogen atoms of azomethine and imino groups of the aminoguanidine fragment. In both complexes, Fe(III) is distorted octahedral. [Fe(PLAG) 2](NO3)3 (2) is the first bis(ligand) complex with this ligand. Cyclic voltammetric characteristics of the ligand and complexes were studied in DMF in the presence of TBAP or LiCl as supporting electrolytes. The complexes are unstable in this solvent, especially in the presence of an excess of chloride, thus forming several reducible species whose stabilities and behaviors were characterized. © 2012 Taylor & Francis.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Rodic_2012_124,

title = {Transition metal complexes with thiosemicarbazide-based ligands: Part 59. Synthesis, structures and electrochemical properties of cobalt(III) complexes with 2-acetylpyridine S-methylisothiosemicarbazone},

author = {M. V. Rodić and V. M. Leovac and L. S. Jovanović and L. S. Vojinović-Ješić and V. Divjaković and V. I. Češljević},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84865797824&doi=10.1016%2fj.poly.2012.08.011&partnerID=40&md5=264ed40617c4a4f75f3831b02df732f9},

doi = {10.1016/j.poly.2012.08.011},

issn = {02775387},

year  = {2012},

date = {2012-01-01},

journal = {Polyhedron},

volume = {46},

number = {1},

pages = {124-132},

abstract = {The paper is concerned with the crystal structure and electrochemical characteristics of the cobalt(III) complexes with 2-acetylpyridine S-methylisothiosemicarbazone (HL), of the coordination formulas [CoL 2]NO 3·MeOH (1), [CoL 2]Br·MeOH (2), [CoL 2]HSO 4·MeOH (3), [CoL 2] 2[Co II(NCS) 4] (4), [Co(HL)(L)]I 2·2 MeOH (5), and [Co(HL)(L)][Co IICl 4]·MeOH (6), as well as of the structure of HL. In all the complexes, Co(III) is situated in a slightly deformed octahedral environment formed by six nitrogen atoms of the two HL molecules in the meridional positions. The ligands coordinate with Co(III) in a usual way, i.e. via the pyridine, azomethine, and isothioamide nitrogen atoms, each forming two five-membered metallocycles. Electrochemical studies of the ligand and the complexes in DMF show that the electrode processes are accompanied by chemical reactions and the corresponding mechanism was proposed. The obtained complexes were also characterized by elemental analysis, conductometric measurements and UV-Vis and IR spectroscopy. © 2012 Elsevier Ltd. All rights reserved.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Guzsvany_2011_4451,

title = {Bismuth modified carbon-based electrodes for the determination of selected neonicotinoid insecticides},

author = {V. Guzsvány and Z. Papp and J. Zbiljic and O. Vajdle and M. Rodic},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-79959582972&doi=10.3390%2fmolecules16064451&partnerID=40&md5=b09723423b7d67fa6cdb4b174a3f39a2},

doi = {10.3390/molecules16064451},

issn = {14203049},

year  = {2011},

date = {2011-01-01},

journal = {Molecules},

volume = {16},

number = {6},

pages = {4451-4466},

abstract = {Two types of bismuth modified electrodes, a bismuth-film modified glassy carbon (BiF-GCE) and a bismuth bulk modified carbon paste, were applied for the determination of selected nitroguanidine neonicotinoid insecticides. The method based on an ex situ prepared BiF-GCE operated in the differential pulse voltammetric (DPV) mode was applied to determine clothianidin in the concentration range from 2.5 to 23 μg cm-3 with a relative standard deviation (RSD) not exceeding 1.5%. The tricresyl phosphatebased carbon paste electrodes (TCP-CPEs), bulk modified with 5 and 20 w/w% of bismuth, showed a different analytical performance in the determination of imidacloprid, regarding the peak shape, potential window, and noise level. The TCP-CPE with 5% Bi was advantageous, and the developed DPV method based on it allowed the determination in the concentration range from 1.7 to 60 μg cm-3 with an RSD of 2.4%. To get a deeper insight into the morphology of the bismuth-based sensor surfaces, scanning electron microscopic measurements were performed of both the surface film and the bulk modified electrodes. © 2011 by the authors; licensee MDPI, Basel, Switzerland.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}